Table 2

Systematic overview of the integrative panel of proteins/functional groups involved in the breast cancer specific molecular patterns in blood cells
Nr. Functional group Relevance for breast cancer in tissue [reference] Relevance for breast cancer in blood [reference]
1 microfilamental network-associated and cytoskeletal-assembly proteins [48,223,224] [11]
2 cell motility, migration & adhesion [225-227] [11]
3 nucleoside / nucleotide turnover & metabolism [228,229]
4 protein metabolism (regulatory protein-synthesis & protein-modification enzymes, chaperons) [230,231] [231]
5 energy metabolism [232-236] [232,236]
6 vitamin metabolism [237,238]
7 mitochondrial proteins [239-241] [239,241]
8 channels, membrane-architecture and intercellular-junction proteins [242]
9 anti-oxidant defence / red-ox control [243-246] [245]
10 detoxification proteins [247]
11 stress-response / -protection related protein [75,248-250]
12 cell-cycle machinery proteins [251-253]
13 heat-shock proteins [254-258]
14 apoptosis-related proteins / protection against apoptosis [259-261] [262,263]
15 tissue-remodelling enzymes [21,264-268]
16 extra-cellular transport & carrier-proteins [258,269,270]
17 signal-transduction proteins / signalling pathways [271-274]
18 longevity / ageing related proteins [275-278]
19 inflammation related / anti-inflammatory proteins [14,21,279]
20 (breast) cancer related inhibitor / promoter see references to individual proteins listed in the Table1
21 cancer invasion and regulator of metastases formation see references to individual proteins listed in Table11

Golubnitschaja et al.

Golubnitschaja et al. EPMA Journal 2013 4:6   doi:10.1186/1878-5085-4-6

Open Data