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Open Access Review

Personalized medicine: myth or reality? The position of Russian clinical pharmacologists

Anna S Zhestovskaja1*, Vladimir G Kukes12 and Dmitry A Sychev12

Author Affiliations

1 Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, I.M. Sechenov First Moscow State Medical University, Trubetskaja 8, Moscow 119991, Russia

2 Federal State Budgetary Institution, Scientific Centre for Expert Evaluation of Medical Products, Petrovskiy Boulevard 8, Moscow 127051, Russia

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EPMA Journal 2013, 4:13  doi:10.1186/1878-5085-4-13

Published: 11 May 2013

Abstract

A personalized medicine, a recent trend of clinical pharmacology, makes possible the individual approach to the choice of the drugs and their dosage. According to the results of a study of the activity of different biomarkers, particularly the isoenzymes of the cytochrome P-450, they provide the efficiency and safety of the pharmacotherapy. The activity of the isoenzymes of the cytochrome P-450 determines an individual pharmacological response and depends on many factors, including genetic ones. The biomarkers of the activity of the isoenzymes of the cytochrome P-450 should be tested in the clinical practice settings using the simple and cheap methods, one of the most available is an immunofluorescent assay. The skilled staff and the centers of personalized medicine are necessary for this approach.

Keywords:
Personalized medicine; Biotransformation; Isoenzymes of the cytochrome P-450