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Introduction into PPPM as a new paradigm of public health service: an integrative view

Tatiana A Bodrova1, Dmitry S Kostyushev2*, Elena N Antonova2, Shimon Slavin7, Dmitry A Gnatenko2, Maria O Bocharova2, Michael Legg5, Paolo Pozzilli6, Mikhail A Paltsev4 and Sergey V Suchkov23

Author Affiliations

1 National Research University ‘Higher School of Economics’, Moscow, Russia

2 I.M.Sechenov First Moscow State Medical University, Moscow, Russia

3 Moscow State Medical Dental University, Moscow, Russia

4 National Research Centre Kurchatov Institute, Moscow, Russia

5 Centre for Health Informatics, Sydney, Australia

6 Department of Endocrinology and Diabetes, Rome University, Rome, Italy

7 The International Center for Cell Therapy & Cancer Immunotherapy (CTCI), Weizman Center, Israel

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EPMA Journal 2012, 3:16  doi:10.1186/1878-5085-3-16

Published: 9 November 2012


In the present state of healthcare, usual medical care is generally given to the already diseased person, while the key link—personal health monitoring underlain by predictive, preventive, and personalised medicine (PPPM) techniques that are being intensively elaborated worldwide—is simply missing. It is this link, based on the recognition of subclinical conditions, prediction, and further preventive measures, that is capable of regulating morbidity and diminishing the rates of disability among able-bodied population, thus significantly cutting the traditionally high costs of treating the already diseased people. To achieve the above-mentioned goal—the elaboration of the PPPM concept and its practical implementation—it is necessary to create a fundamentally new strategy based upon the subclinical recognition of the signs—bioindicators of cryptic abnormalities long before the disease clinically manifests itself. The implementation of PPPM programme requires an adjusted technology for the proper interpretation of diagnostic data, which would allow for the current ‘physician-patient’ model to be gradually replaced by a novel model, ‘medical advisor-healthy men-at-risk’. This is the reason for an additional need in organising combinatorial scientific, clinical, training and educational projects in the area of PPPM to elicit the content of this new branch of medicine.

Predictive; preventive; and personalised medicine; Subclinical; Omics; Bioinformatics; Biopredictors; Biomarkers; Ethics; Policy; Legacy; Economy; Integrative medical approach